Prosthetic vision

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picture of Argus II retinal prosthesis Since 2007, Dr. Arditi has been a site Principal Investigator (PI) of the Columbia Presbyterian/Lighthouse International feasibility study of Second Sight Medical Products' Argus II retinal prosthesis. In collaboration with Lucian del Priore, MD and Stephen Tsang, MD (the PIs at Columbia-Presbyterian Hospital), and many others from sites around the world, we have been evaluating a retinal prosthesis for advanced retinitis pigmentosa, invented by Mark Humayun, MD (University of Southern California) that consists of surgically implanted electronics and a 60-electrode stimulating array tacked directly onto the retina in conjunction with an externally worn wearable computer. In the picture at the left, A shows the components of the Argus II device that are worn by the user externally. B illustrates the components that are surgically implanted in and around the user's eye.

In July of 2009, the first and only subject in New York city was implanted with the device, and Dr. Arditi conducted all of the psychophysical testing and training of this subject. Second Sight, in September 2012 received the unanimous approval of a US Food and Drug Administration panel, a crucial step towards approval for limited marketing of this device. Dr. Arditi continues his studies with the subject at Lighthouse International, and also has recently begun studying other visual prosthetic approaches to navigation, wayfinding, and other functional tasks [1,2,3,4]. For more information about this exciting bionic eye project, see this paper. Also see our page on navigation and wayfinding.

Relevant publications

Humayun M, Dorn J, da Cruz L, Dagnelie G, Sahel J, Stanga P, Cideciyan A, Duncan J, Eliott D, Filley E, Ho A, Santos A, Safran A, Arditi A, Del Priore L, Greenberg R, Argus Study Group, (2012) Interim Results from the International Trial of Second Sight’s Visual Prosthesis., Ophthalmology, 119(4), 779-788.

Li, B., Muñoz, J. P., Rong, X., Chen, Q, Xiao, J., Tian, Y, Arditi, A., Yousuf, M. (2018). Vision-based Mobile Indoor Assistive Navigation Aid for Blind People IEEE Transactions on Mobile Computing, in press, doi:10.1109/TMC.

Geruschat D R, Richards T P, Arditi A, da Cruz L, Dagnelie G, Dorn J, Duncan J L, Ho A C, Olmos de Koo L C, Sahel J, Stanga P E, Thumann G, Wang V, and Greenberg R J (2016) An analysis of observer-rated functional vision in patients implanted with the Argus II Retinal Prosthesis System at three years, Clinical and Experimental Optometry, http://dx.doi.org/10.1111/cxo.12359

Da Cruz, L. Dorn, J.D., Humayun, M.S., Dagnelie, G., Handa, J., Barale, P-O, Sahel, J-A., Stanga, P.E., Hafezi, F., Safran, A.B., Salzmann, J., Santos, A., Birch, D., Spencer, R. Cideciyan, A.V., de Juan, E., Duncan, J.L., Eliott, D., Fawzi, A., Olmos de Koo, L.C., Ho, A.C., Brown, G., Haller, J., Regillo, C., Del Priore, L., Arditi, A., Greenberg, R.J., for the Argus II Study Group. (2016) Five-year safety and performance results from the Argus II Retinal Prosthesis System clinical trial., Ophthalmology, http://dx.doi.org/10.1016/j.ophtha.2016.06.049

Dagnelie, G., Christopher, P., Arditi, A., da Cruz, L., Duncan, J. L., Ho, A. C., de Koo, L. C. O., Sahel, J. -A., Stanga, P. E., Thumann, G., Wang, Y., Arsiero, M., Dorn, J. D., Greenberg, R. J., and the Argus® II Study Group (2016) Performance of real-world functional vision tasks by blind subjects improves after implantation with the Argus® II retinal prosthesis system. Clinical & Experimental Ophthalmology, doi: 10.1111/ceo.12812.

Rong, X., Li, B. Muñoz, Xiao, J., Arditi, A. & Tian, Y.. Guided Text Spotting for Assistive Blind Navigation in Unfamiliar Indoor Environments Advances in Visual Computing: 12th International Symposium,Springer International Publishing, 11-22, doi: 10.1007/978-3-319-50832-0_2

Ho,A C, Humayun M S, Dorn J D, da Cruz L, Dagnelie G, Handa J, Barale P, Sahel J, Stanga P E, Hafezi F, Safran A B, Salzmann J, Santos A, Birch D, Spencer R, Cideciyan A V, de Juan E, Duncan J L, Eliott D, Fawzi A, Olmos de Koo L C, Brown G C, Haller JA, Regillo C D, Del Priore L V, Arditi A, Geruschat D R, Greenberg R J, for the Argus II Study Group, (2015) Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind, Ophthalmology, http://dx.doi.org/10.1016/j.ophtha.2015.04.032

Arditi, A. (2014) Auditory display of coarse optical imagery: Concept for a rehabilitation aid for blind spatial orientation. In Proceedings of the 20th International Conference on Auditory Display.. Atlanta, Georgia: Georgia Institute of Technology. Also available at https://smartech.gatech.edu/handle/1853/52080

Arditi, A., and Tian, Y. (2013). User Interface Preferences in the Design of a Camera-Based Navigation and Wayfinding Aid. Journal of Visual Impairment & Blindness, 107 (2), 118-129.

Yi, C., Tian, Y. & Arditi, A.(2013). Portable Camera-based Assistive Text and Product Label Reading from Hand-held Objects for Blind Persons IEEE/ASME transactions on mechatronics. doi:10.1109/TMECH.2013.2261083

Tian, Y., Yang, X., Yi, C. and Arditi, A. (2013) Toward a Computer Vision-based Wayfinding Aid for Blind Persons to Access Unfamiliar Indoor Environments”, Machine Vision and Applications, 24(3), 521-535. doi: 10.1007/s00138-012-0431-7. NIHMSID # 371367

Yuan, S., Tian, Y. L., & Arditi, A. (2011). Clothing matching for visually impaired persons. Technology and Disability, 23(2), 75-85.

Tian, Y., Yi, C. and Arditi, A. (2010). Improving Computer Vision-Based Indoor Wayfinding for Blind Persons with Context Information. In K. Miesenberger et al. (Eds.): ICCHP 2010, Part II, LNCS 6180, Berlin: Springer-Verlag pp. 255–262.

Yang, X., Tian, Y., Yi, C., & Arditi, A. (2010). Context-based indoor object detection as an aid to blind persons accessing unfamiliar environments. Proceedings of the international conference on Multimedia (pp. 1087-1090). ACM.

Tian, Y., Yang, X. and Arditi, A. (2010). Computer vision-based door detection for accessibility of unfamiliar environments to blind persons. Paper presented at the International Conference on Computers Helping People with Special Needs, Vienna, Austria.

Tian, Y., Yi, C. and Arditi, A. (2010). Improving Computer Vision-Based Indoor Wayfinding for Blind Persons with Context Information. Paper presented at the International Conference on Computers Helping People with Special Needs, Vienna, Austria.

Humayan, M. (2010). Arditi, A. , Barale, P. , Birch, D., Cideciyan, A., da Cruz, L., Dagnelie, G., Duncan, J., Eliott, D., Ho, A., de Juan, E., Del Priore, L., Safran, A., Stanga, P., & Greenberg, R. (2010). Interim Performance Results from the Second Sight® ArgusTM II Retinal Prosthesis Study. Paper to be presented at the annual meeting of the American Society of Retina Specialists. Vancover, BC. August.

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